@donc The results were rather interesting...
Bone to pick with OFA
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I am glad your girl will probably NOT get fanconi
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A german breeder just got such a letter yesterday, too.
The results of the 3 girls of her last litter changed.
The Clear ones are Carriers now and the Carrier Clear.
One or two will probably be bred at one day, so they will have to do the test again in a few month… -
If you make the OFA aware of the change in results, they will ask you for a new sample to run the test on and will do it again, probably free of charge.
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Pip came back Ind from clear parents, I was never happy about the result and plan to re-do it at sometime.
Someone over here had her dog re-tested as it came back carrier, the parents were both clear, retest came back clear.
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Pip came back Ind from clear parents, I was never happy about the result and plan to re-do it at sometime.
Someone over here had her dog re-tested as it came back carrier, the parents were both clear, retest came back clear.
I am not sure why you would not be happy with these results.
It is your dogs DNA that shows it is Indeterminate.
It has NOTHING to do with the test.
The DNA is not showing all 'clear' genes.
If both parents tested as clear, you can figure when the direct test comes out, yours may just do that also…
but this is not a direct test...
and DNA can be funky and not show that they are looking for in this "mass" of genes.I see so many folks complaining....
Sorry, but I think those complaining need to take a closer look.
I have seen Fanconi Syndrome for YEARS.
I never ever thought there would be a test in my lifetime.
And I am only 42 years of age.
This test is beyond my wildest dreams.
We are LUCKY it is here today.
Rejoice in the fact that you do NOT need to live with Fanconi Syndrome any more.
Though, I am seeing more foreign [non-USA] born litters that are producing affecteds…..
which is incredibly dismaying.
There is NO reason to breed a litter without testing the parents first.Having lived with Fanconi Syndrome and produced plenty of it,
I know the ramifications and don't dare put any prospective puppy owners in the position of having a pup that could eventually come down with FS. It just isn't worth it.. not at any cost. -
I am not sure why you would not be happy with these results.
It is your dogs DNA that shows it is Indeterminate.
It has NOTHING to do with the test.
The DNA is not showing all 'clear' genes.
If both parents tested as clear, you can figure when the direct test comes out, yours may just do that also…
but this is not a direct test...
and DNA can be funky and not show that they are looking for in this "mass" of genes.The person didn't say INDETERMINATE in the section you quoted they said CARRIER and that is an issue. Two CLEARS should NOT produce a CARRIER. If that is a "real" result then the lab needs to take a serious look at the markers they are using. If it is an "error" result then the lab needs to do some serious QC to make sure that their clients are getting correct results.
DNA follows some very specific rules. Even with mutation there is expected outcomes and markers are chosen with this in mind.
Errors happen in all labs, it is how they are handled that really separates labs. It is good that they caught the mistake but if the letter explaining what happened did not answer your questions and did not include a contact number so you could discuss your specific situation then I can fully understand everyone's frustration. If the only reason people are upset is because an error happened then everyone needs to remember labs are run by humans and humans make mistakes.
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That is an issue ivoss. I had two clears produce an affected. I had the test redone and it came back carrier. I know I had it done a third time, and I believe it was carrier that time as well. I had the AKC do a DNA parentage and the mother on paper was not really Medjai's mother. His real mother was also clear though.
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There is one other issue with the DNA tests and that is that they rely on the owners to honestly sample the correct dogs. This would seem a no brainer, that no one would want to willfully lie when this test can prevent disease but experience suggests that is not always the case.
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I guess I am glad I started this thread, as I had never heard of any of these issues with the test previously. I agree that the fact that we have the test at all is a blessing for anybody that breeds Basenjis. So it is hard to complain about any of the details. We are not breeders and just wanted to know if our Ella would develop Fanconi. At this point, even with the test, I think the answer is not certain.
I will vent just a tiny bit of frustration one more time to all those who have reasonably stated that "tests are run by humans and humans make mistakes."
We all make mistakes but the difference is how we handle those mistakes. They could have been a little more understanding. I was quite put off by the form letter that i got, which was a total of 2 sentences and made no reference to why the original test results were thrown out or whether there would be any reason to re-test again. There was no offer to engage me to contact them for more information if I wanted it. They did not even include a simple guide to the test results which came with the original results, so that I had to dig through my old paperwork to even figure out what the new results mean. I know that it is professional scientific organization, but just a little more information and compassion along with the new results would have gone a long way, I think. It is probably too much to ask.
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We all make mistakes but the difference is how we handle those mistakes. They could have been a little more understanding. I was quite put off by the form letter that i got, which was a total of 2 sentences and made no reference to why the original test results were thrown out or whether there would be any reason to re-test again. There was no offer to engage me to contact them for more information if I wanted it. They did not even include a simple guide to the test results which came with the original results, so that I had to dig through my old paperwork to even figure out what the new results mean. I know that it is professional scientific organization, but just a little more information and compassion along with the new results would have gone a long way, I think. It is probably too much to ask.
These are valid reasons for being upset. You paid good money for the test and should have an expectation that you would be treated professionally by the lab. They should be willing to talk to their clients when an issue like this arises, it is part of the job and should not be too much to ask.
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However, remember you did NOT get a letter from the LAB, right, it came from OFA, correct?
While I agree it should have been the lab that contacted you and advise of the error, I would not expect OFA to be the one providing the explanation, OFA is just the source were the results are listed.
Just want to make it clear that we are talking about how the Lab should have handled errors
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In all honesty, "the lab" and "OFA" are not truly separate in the case of our DNA tests. OFA has contracted with the lab at U of Mo and since the order is placed through the OFA website, I would have an expectation that OFA would answer questions with regards to my results and provide contact information to the lab in cases such as these. OFA does not get an out when you are ordering these services directly from their website. It would be a different situation if you were placing your orders through the lab's independent website, where you then have contact information for the lab and the expectation would be the lab would be the primary contact. If OFA does not want the job of dealing professionally with errors that occur in their contract lab then they should not be selling the tests through their website.
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I guess we will have to agree to disagree on that.
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One of Apache's sister was tested about three months ago and came back as a "clear"…now her owner just got a letter saying she's "probably affected". Seems the lab has been screwing up an awful lot lately.
I agree that they aren't handling these issues with much thought to the owners of these dogs. It's one thing to have a clear result and then get a carrier result, at least you still know your dog shouldn't (I say that only because if they screwed up once who's to say they didn't the second time) ever get the disease, but to get a clear result and then AN AFFECTED with just a few sentences on a letter...that's cruel.
I think they should send a new test kit out right away and ask for a new swab rather than retesting what they have, it shouldn't be up to the owners to call and request that.
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Gosh this thread is making me paranoid…
I know that labs make mistakes, but I do hope it just happens in one "batch", something that can be attributed to a technical error, and not something that happens systematically as part of the process.
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Does anyone know of the actual process involved in the testing? I guess what I am asking is - is it possible that someone at the lab (maybe a new person) did not complete the test/read it properly?
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There is always the question of human error. We've had batches of breast cancer checks over here where the results were misread by an individual and people told they were clear when they weren't.
However these cases are rare but that doesn't help whenit happens to you, it's a cruel thing to happen..
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I wasn't happy with my Ind result from two clear parents because I told them before I sent the swab back that I wasn't happy with it and would have liked another swab. It was tested anyway and I almost expected a wrong result.
It wasn't necessarily an error at the lab but human error before they ever received it (on my part) I think they should have sent another swab, I would have been happy to pay for it. I was told if I wanted a repeat test I would have to start from scratch and pay all over again.
