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  3. DNA testing for Pyruvate Kinase Deficiency…

DNA testing for Pyruvate Kinase Deficiency…

Basenji Health Issues & Questions
  • sabaS

    I am getting myself organised to continue with my health testing, of Ochre and Saba. Saba is booked in this week to get his Hips/Elbows done, and he has already had his Fanconi done. Ochre is about to have her cheek swab done for Fanconi, just waiting to hear back from Genetic Technologies re that…

    When I got some documentation from this company, it has a list of all the diseases that can be DNA tested for all the different breeds. Listed under the Basenji was Pyruvate Kinase Deficiency, (PK). (Interesting that Fanconi wasnt listed either :confused:)This stumped me as I had not heard of this disease in relation to the Basenji...

    Is this something that should be routinely tested for ??? I will be doing some "homework", in relation to this disease, but Im just interested in people's thoughts :) Do I need to get it done ???

    Home of -

    Wazazi Dressed To Dazzle (Saba).Australian Champion Wazazi High Expectations (Ochre). Wazazi Living Doll (Vanda). Langarni African Aluko (Java).

    www.langarni-rajacadoo.com

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  • tanzaT

    PK testing is for Hemolytic Anemia, mostly not seen in Basenjis today. Like Fanconi it is a recessive gene…. you can read about it at www.basenji.org or www.basenjihealth.org and it was a big problem 30 yrs ago (I may be wrong on the date.. it was before my time in Basenjis)

    Pat Fragassi

    Tanza Basenjis

    www.tanzabasenjis.net

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  • sabaS

    Thanks Tanza :).

    Well you can see that I didnt do my homework on this disease BEFORE I posted my question :o:o.

    (Says this, then runs off to commence my edumacation for the day. Topic is… H.A. :))

    Home of -

    Wazazi Dressed To Dazzle (Saba).Australian Champion Wazazi High Expectations (Ochre). Wazazi Living Doll (Vanda). Langarni African Aluko (Java).

    www.langarni-rajacadoo.com

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    @AC~Akeyla: I was wondering when we should have our 1 year old B's checked for Fanconi? For some reason I thought they had to be a certain age. And what is the best way to go about getting them tested? And you are most likely thinking of the urine test strips, which was the only way to detect Fanconi before the DNA Test that is now widely used. Since Fanconi is a late onset, usually it was recommended that Basenjis be strip test with urine test strips beginning no later then age 3 (and tested once a month, every month). If you have a Basenji that DNA tests for Affected, then you still will need to start testing them monthly no later then age 3.
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    @wizard: I've looked at that website but still don't understand the reason behind doing this test. It doesn't check for genetic defects just parentage. It seems it undeniably verifies parentage, but isn't that what the AKC registration does? There must be something I'm missing. It is to prove parentage… as you could put any name of any dog on a set of papers and sent them it.... which in cases of Puppy Millers and some BYB's that is was was being done..... so the parents were NOT the parents of a given puppy. If you read the minutes each month on the AKC site (Secretary's page) you can see how many litter registrations were reversed "due" to DNA parentage.
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    @etzbseder: Thanks, I've seen that before, but forgot about it. After looking at that, it shows that my answer would be: Clear pups ONLY means that neither parent is affected, and that does not change with multiple clear pups. The only thing that shows any determination of the parents is a test of the parent themselves (or if their grandparents are clear). correct. The more clear pups (with no affecteds or carriers) you had from the breeding of the same two animals, the more LIKELY it is that the parents are clear…but it certainly would not be a for sure.
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    What tests

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    @jessi76: another vac I didn't see on your list is Lyme. Ask your vet about it IF tics are prevelant in your area. where I live, ALOT of dogs are coming down with Lyme disease (spread by deer tics), so I didn't even think twice about getting my dog the vaccine. although we keep him on a flea & tic preventative, the vaccine is another added precaution. like I said though, only if tics are an issue in your area. No, they don't seem to be a big deal here, the worst "pest" we have aside from fleas are chiggers or you may know of them as sand fleas. Thanks for you help.