Skip to content

If sib is "clear" do I need to test brother?

Basenji Health Issues & Questions
  • Then where does the "indeterminate" result come from?

  • The "interdeterminate" result comes when a dog has inherited an incomplete set of markers. When this happens there is no way to know whether they have the inherited the gene with the partial set of markers or not so they are labeled "indeterminate".

  • im still confused, how can you have indeterminate between clear and carrier but not between carrier and affected and why does a lot of family members come back as indeterminate between clear and carrieri could understand if it was only one or two but it is most of them

  • Since this is just a marker test, "Indeterminate" results mean that some of the markers are found, and some are not. So the gene could be present, or not present. Indeterminate actually could be affected, carrier or clear, it is just not possible to tell, because the markers are incomplete.

    Marker testing is a little trickier than direct testing. It is good, but there are holes in the test, since the genes and markers aren't totally "fixed" in their positions on the genome. Markers and the genes they are used to track can become separated by mutations.

  • @jules:

    im still confused, how can you have indeterminate between clear and carrier but not between carrier and affected and why does a lot of family members come back as indeterminate between clear and carrieri could understand if it was only one or two but it is most of them

    I was at the 2007 Nationals and asked about this and they said that they just haven't seen any Indeterminate between Carrier and Affected at that time. I find that hard to believe also but the lab is sticking to that explanation.

    As far as some families have lots of IND, an IND has 1 set of markers for Clear and one IND set so when bred according to the guidelines they will produce either Clear or IND offspring. It also seems that in some families that area is more prone to changes so high rates of IND occur. The lab is working to zero in on the gene so all of the IND results can be resolved.

  • well i know of one family that produced affected and IND in the same litter that was why i was asking i will be glad when the gene is found then we can all be sure

  • A carrier can produce, Carriers, Affecteds, Clears, and IND depending on who they are bred to.

  • what about a carrier to an IND

  • I have seen them produce Affected but those dogs really should be Indeterminate between Carrier and Clear but the lab never responded about that.

    The possible outcomes should be Clear, Carrier, IND, Indeterminate between Carrier and Affected based on the explanation the lab has given us.

  • i have seen ind and affected in the same litter

Suggested Topics

  • 0 Votes
    25 Posts
    11k Views
    BettawhippetB
    That is a huge relief about the cheek swab…She absolutely HATED having her blood drawn and has been mistrustful of the vet and vet techs ever since. I didn't not realize that there were many errors in the original test. I stopped frequenting this forum shortly after I had her test done and haven't really heard anything from the basenji world until I got the e-mail. I will definitely get this re-test done as soon as possible and will pick up some strips tomorrow so I can start testing her urine. Thankfully she has not been showing any signs of poor health and has always done well on checkups.
  • 0 Votes
    5 Posts
    4k Views
    tanzaT
    The level of sound on a "debark" can range from a whisper to pretty loud, depends on the Vet that does the debark and how good he/she is….
  • Fanconi "Symptom"?

    Basenji Health Issues & Questions
    15
    0 Votes
    15 Posts
    6k Views
    S
    Glad the report you got is good…let us know how it goes.
  • The "A" siblings!

    Basenji Health Issues & Questions
    6
    0 Votes
    6 Posts
    2k Views
    thunderbird8588T
    Great news
  • When to test?

    Basenji Health Issues & Questions
    4
    0 Votes
    4 Posts
    2k Views
    tanzaT
    @AC~Akeyla: I was wondering when we should have our 1 year old B's checked for Fanconi? For some reason I thought they had to be a certain age. And what is the best way to go about getting them tested? And you are most likely thinking of the urine test strips, which was the only way to detect Fanconi before the DNA Test that is now widely used. Since Fanconi is a late onset, usually it was recommended that Basenjis be strip test with urine test strips beginning no later then age 3 (and tested once a month, every month). If you have a Basenji that DNA tests for Affected, then you still will need to start testing them monthly no later then age 3.
  • 0 Votes
    25 Posts
    12k Views
    RockysWomanR
    Speaking of "desinger" breeds… my dh (for the longest time!) was trying to convince me to breed our Papillion to a mini daschund. All I could picture was huge ears that may or may not flip up at a moments notice, a super long body, and long legs. It would look like something out of a Salvidor Dali picture!!! EEk!