Since you are taking a very long international flight I would suggest getting some rescure remedy and giving her some. Also, freeze water in her crate cup and put it in to crate right before leaving for the airport. I don't usually feed my guys when flying internatioanlly but because your flight will be so long I'd put food in there for her also.
Next make sure that your vet is USDA certified. Here is some info if he/she is not
Turkey does not quarantine healthy pets with proper documents.
Your Veterinarian should complete a veterinary certificate stating that the pet is healthy, free of parasites, and free of diseases communicable to humans. This certificate should be signed by the veterinarian not more than 15 days prior to travel.
Your pet must have a rabies vaccination at least 30 days prior to travel but not more than 12 months prior to entering Turkey.
The veterinarian should sign this form not more than 15 days prior to the travel date.
If above documents are given by a accredited veterinarian OR if they are approved by U.S. Department of Agriculture accepted by Turkish authorities, it is not necessary that the documents be legalized by the Turkish Embassy's Consular Section or a Turkish Consulate General - SEE NEXT PARAGRAPH.
If your veterinarian is NOT a licenses USDA veternarian then the final step is to send the veterinary certificate along with the rabies vaccinatin certificate to the Turkish Consulate with a payment of $3.00
The Turkish Consulate will then endorse the certificate so that you can enter Turkey
Each traveler can bring one bird and one dog into the Country
Turkey does not require that your pet be microchipped.
Turkey requires a veterinary certificate.
American Airlines does take good care of your pets, but yes they are handled by baggage handlers. And the good thing is pets are the last to go on the plane and first to come off, and of course placed in a climate control pressurized area.
As for her kennel, (I'm only noticed this on newer models) after her kennel has been inspected at the airport (it's right before they take them away) zip tie her door closed for added security. If her kennel doesn't not have the extra holes to do this, you can easily add them just by drilling holes. Best to do two at the top and two at the bottom. Oh, yes one more thing, for international travel her kennel must be vented on all 4 sides. It is becoming more standard for kennels to be four way vented but not always.
I would also put a non destructable toy in there with her. Make sure she is wearing a collar with identifaction tags, if possible get something made with contact info you may have in Turkey. You can tape a leash to the top of the crate but I prefer not to because it may become lost. Add a sign on the crate stateing something along the lines of "please don't open my crate, I can run very fast." Sometimes they require food to be taped to the top of the crate and this is fine with the sign the food can be poured into the bowl with the door still closed.
And please feel free to ask anymore questions you may have I have flown many times with my dogs, and never a problem.