If sib is "clear" do I need to test brother?


  • Mutation can occur at any time! There is never a guarantee only a probability.

    However mutation is a rare occurrence so don't panic anyone!


  • fantastic results, congrats!


  • A whole new world has opened up to me since I joinned this forum and learning to navaigate it.

    I 've had my Belle since she was 8 weeks old, no history on her parents…she is wonderful. Getting to know this breed has been quit a journey.
    Now I have two rescure B's, brothers , no history, and they are my forever dogs now!:)

    They were in poor condition when I got them, 10 weeks ago, I've got their skin condition's healed and under controll....weight gain, happy campers now.

    Sooooo, testing....what do I need to get, to do the test myself or is the vet the best way.

    Anything you can tell me, there is a wealth of experience out here and I need to learn more now that I have this pack.

    I love this breed, they match my personality..... to

    Let moi know,

    Baroooos & toe kisses form the Hart Pack, Belle, Ra & Shango:)


  • Hi

    You can download information you need at: http://www.basenjihealth.org/linkage-faq.html. I purchased the test online, they sent the kit (it is very easy to obtain the sample-it is a saliva sample), I sent it to them, and I got results in about four weeks.

    Hope that helps. Looks as though you have your hands full. I agree with you; basenjis are the only breed. :)

  • Houston

    Cindy,
    I did the same thing. Go online, get the kits in the mail, take the test (easy check swab) in the AM, before food has been given, careful not to touch the test with your hands, send it off and wait a week or two for answers, that by the way is the hardest, the wait.. Very easy to do, and painless for the dog..

    By the way, as far as doing both Ra and Shango, I would do it as you do not know about their parents.


  • Thanks,

    Geez, this is like some of my friends waiting on there AIDS testing…..I'll order soon. Lets try and set a play date next week Tuesday and Thursdays are good for me

    Later :cool:

  • Houston

    Either day is good for me as well. Let's see how the weather is supposed to be, maybe we will get that cool front they were talking about..


  • Knowing what to expect is so wonderful..if the dog is clear or a carrier, then its a weight off your mind, if its affected, then you know how to educate yourself to get ready for what might happen.
    Do let us know.
    We will be there for you.


  • how can one family of basenjis have the majority of them come back indeterminate? this puzzles me as one did come back affected


  • I have some knowledge of genetics, and I can explain a little about the 'indeterminate' finding. Fanconi is not a single loci disorder. Multiple genes in several locations are involved in a 'probably affected' result. 'Indeterminate' results usually carry affected type results in some of the locations, but not all of them.

    Hope this helps


  • That is not correct, Fanconi is believed to be a single locus disorder but the locus has not been precisely indentified at this time. The current test is not testing for the actual gene which has not yet been discovered but instead uses three markers that are a located in close proximity to the gene. When 1 or more of these markers separates from the others due to crossing over during Prophase I of meiosis there is no way to tell which markers the gene went with.


  • Then where does the "indeterminate" result come from?


  • The "interdeterminate" result comes when a dog has inherited an incomplete set of markers. When this happens there is no way to know whether they have the inherited the gene with the partial set of markers or not so they are labeled "indeterminate".


  • im still confused, how can you have indeterminate between clear and carrier but not between carrier and affected and why does a lot of family members come back as indeterminate between clear and carrieri could understand if it was only one or two but it is most of them


  • Since this is just a marker test, "Indeterminate" results mean that some of the markers are found, and some are not. So the gene could be present, or not present. Indeterminate actually could be affected, carrier or clear, it is just not possible to tell, because the markers are incomplete.

    Marker testing is a little trickier than direct testing. It is good, but there are holes in the test, since the genes and markers aren't totally "fixed" in their positions on the genome. Markers and the genes they are used to track can become separated by mutations.


  • @jules:

    im still confused, how can you have indeterminate between clear and carrier but not between carrier and affected and why does a lot of family members come back as indeterminate between clear and carrieri could understand if it was only one or two but it is most of them

    I was at the 2007 Nationals and asked about this and they said that they just haven't seen any Indeterminate between Carrier and Affected at that time. I find that hard to believe also but the lab is sticking to that explanation.

    As far as some families have lots of IND, an IND has 1 set of markers for Clear and one IND set so when bred according to the guidelines they will produce either Clear or IND offspring. It also seems that in some families that area is more prone to changes so high rates of IND occur. The lab is working to zero in on the gene so all of the IND results can be resolved.


  • well i know of one family that produced affected and IND in the same litter that was why i was asking i will be glad when the gene is found then we can all be sure


  • A carrier can produce, Carriers, Affecteds, Clears, and IND depending on who they are bred to.


  • what about a carrier to an IND


  • I have seen them produce Affected but those dogs really should be Indeterminate between Carrier and Clear but the lab never responded about that.

    The possible outcomes should be Clear, Carrier, IND, Indeterminate between Carrier and Affected based on the explanation the lab has given us.

Suggested Topics

  • 0 Votes
    5 Posts
    4k Views
    tanzaT
    The level of sound on a "debark" can range from a whisper to pretty loud, depends on the Vet that does the debark and how good he/she is….
  • Health Tests

    Basenji Health Issues & Questions
    6
    0 Votes
    6 Posts
    2k Views
    lvossL
    The fanconi test needs to be ordered from the OFA website, https://secure.offa.org/cart.html Have you talked to Nilo's breeder about health testing. Without pedigree information his tests alone don't provide a very complete picture since disorders like PRA are late onset.
  • The "A" siblings!

    Basenji Health Issues & Questions
    6
    0 Votes
    6 Posts
    2k Views
    thunderbird8588T
    Great news
  • "Bone"?

    Basenji Health Issues & Questions
    11
    0 Votes
    11 Posts
    5k Views
    P
    I've only just read this post as I was away for a few days. I couldn't agree more with Tanza about substantial and bladed bone. The UK standard calls for fine bone which is interpreted by some to mean 'weedy'. As Tanza says it is not all black and white. After all the term 'fine' is open to individual interpretation. I had a look on your website Tanza and agree that Maggii is very feminine and has good bone.
  • Update on Booger's "allergies"

    Basenji Health Issues & Questions
    19
    0 Votes
    19 Posts
    4k Views
    AndrewA
    @tanza: Not to put any pressure on you or the Vet.. but to me… blood work is one of the most important tools.... and I am surprised that at least even with an appointment next week ... that they didn't take blood while he was there.... If it was me... and I am a "freak" about doing blood panels.. I would have insisted on at least that..... Thanks for letting me know. As Booger & Lola are my first "grown up" dogs (my parents took care of sick dogs growing up & we never had many issues until 1 got cancer), I really honestly don't know all the things I should be looking for or asking about. I will definitely call & ask about that. Booger does seem a LOT better today than he did yesterday, which is good. I don't take this as much of a sign of anything, but it at least makes me feel better knowing he isn't so miserable. He's a lot perkier & more playful. He gave us some playful baroos earlier, too, which is a rare treat!
  • 0 Votes
    25 Posts
    12k Views
    RockysWomanR
    Speaking of "desinger" breeds… my dh (for the longest time!) was trying to convince me to breed our Papillion to a mini daschund. All I could picture was huge ears that may or may not flip up at a moments notice, a super long body, and long legs. It would look like something out of a Salvidor Dali picture!!! EEk!